Water → 4-acetamino-3-methyl-N-(beta-methanesulfonamidoethyl)-N-ethylaniline

HRID 436545

反応式

HRID 436545 の反応式
[NH:1]([C:5]1[CH:13]=[CH:12][C:8]([NH:9][CH2:10][CH3:11])=[CH:7][C:6]=1[CH3:14])[C:2]([CH3:4])=[O:3].[CH3:15][S:16]([NH:19][CH2:20][CH2:21]Cl)(=[O:18])=[O:17].C(=O)([O-])O.[Na+].O>CO>[NH:1]([C:5]1[CH:13]=[CH:12][C:8]([N:9]([CH2:21][CH2:20][NH:19][S:16]([CH3:15])(=[O:18])=[O:17])[CH2:10][CH3:11])=[CH:7][C:6]=1[CH3:14])[C:2]([CH3:4])=[O:3]

参加物

6

反応物 4

HCID 962WaterHCID 89092N-(2-Chloroethyl)methanesulphonamideHCID 516892Sodium BicarbonateHCID 214528314-Acetamino-3-methyl-N-ethylaniline

生成物 1

HCID 214528344-acetamino-3-methyl-N-(beta-methanesulfonamidoethyl)-N-ethylaniline

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 57.6g of 4-acetamino-3-methyl-N-ethylaniline, 52g of βmethanesulfonamidoethyl chloride, 27.7g of sodium hydrogen carbonate, 70g of water and 70ml of methanol were refluxed for 5 hours, and thereafter the methanol was distilled out under reduced pressure. Water was added to the reaction system and an oily product separated out. This oily product was poured into ethyl acetate and cooled to obtain white 4-acetamino-3-methyl-N-(β-methanesulfonamidoethyl)-N-ethylaniline.

後処理

  1. temperaturewere refluxed for 5 hours
  2. distillationthe methanol was distilled out under reduced pressure
  3. additionWater was added to the reaction system
  4. customan oily product separated out
  5. additionThis oily product was poured into ethyl acetate
  6. temperaturecooled

出典と根拠

ORDレコード
ord-0415ffa5af224365b1f5a0fffd76f923
出典データセット
uspto-grants-1977_02
特許番号
US04009205

関連ノート

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