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Water → 4-acetamino-3-methyl-N-(beta-methanesulfonamidoethyl)-N-ethylaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | N-(2-Chloroethyl)methanesulphonamide | HCID 89092 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 4-Acetamino-3-methyl-N-ethylaniline | HCID 21452831 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-acetamino-3-methyl-N-(beta-methanesulfonamidoethyl)-N-ethylaniline | HCID 21452834 | — |
反応手順
A mixture of 57.6g of 4-acetamino-3-methyl-N-ethylaniline, 52g of βmethanesulfonamidoethyl chloride, 27.7g of sodium hydrogen carbonate, 70g of water and 70ml of methanol were refluxed for 5 hours, and thereafter the methanol was distilled out under reduced pressure. Water was added to the reaction system and an oily product separated out. This oily product was poured into ethyl acetate and cooled to obtain white 4-acetamino-3-methyl-N-(β-methanesulfonamidoethyl)-N-ethylaniline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04009205 |
| 出典データセット | uspto-grants-1977_02 |
| ORD ID | ord-0415ffa5af224365b1f5a0fffd76f923 |
| 出典メモ | uspto-grants-1977_02 |