反应详情

A mixture of 57.6g of 4-acetamino-3-methyl-N-ethylaniline, 52g of βmethanesulfonamidoethyl chloride, 27.7g of sodium hydrogen carbonate, 70g of water and 70ml of methanol were refluxed for 5 hours, and thereafter the methanol was distilled out under reduced pressure. Water was added to the reaction system and an oily product separated out. This oily product was poured into ethyl acetate and cooled to obtain white 4-acetamino-3-methyl-N-(β-methanesulfonamidoethyl)-N-ethylaniline.

1. temperaturewere refluxed for 5 hours
2. distillationthe methanol was distilled out under reduced pressure
3. additionWater was added to the reaction system
4. customan oily product separated out
5. additionThis oily product was poured into ethyl acetate
6. temperaturecooled