Cystamine Dihydrochloride → N,N'-(Dithiodiethylene)bis(4-trifluoromethoxybenzamide)
反応式
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:12]=[CH:11][C:7]([C:8](Cl)=[O:9])=[CH:6][CH:5]=1.Cl.Cl.[NH2:17][CH2:18][CH2:19][S:20][S:21][CH2:22][CH2:23][NH2:24].[OH-:25].[Na+]>C(Cl)CCl>[CH2:19]([S:20][S:21][CH2:22][CH2:23][NH:24][C:8](=[O:9])[C:7]1[CH:11]=[CH:12][C:4]([O:25][C:2]([F:1])([F:13])[F:14])=[CH:5][CH:6]=1)[CH2:18][NH:17][C:8](=[O:9])[C:7]1[CH:11]=[CH:12][C:4]([O:3][C:2]([F:14])([F:13])[F:1])=[CH:5][CH:6]=1参加物
5
実験手順
m.p. 150°-151° C., 14.5 g., was prepared as in Example 1 using 33.6 g. of 4-trifluoromethoxybenzoyl chloride in 100 ml. of ethylene dichloride, 11.3 g. of cystamine dihydrochloride, 300 ml. of 10% sodium hydroxide solution, 400 ml. of ethylene dichloride and recrystallization from acetonitrile using decolorizing charcoal.