Chloride → N-[3-(propionylamino)phenyl]cyclopropanecarboxamide

HRID 436681ノート

反応式

HRID 436681 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[NH:5][C:6](=[O:9])[CH2:7][CH3:8].C([O-])(=O)C.[Na+].[CH:18]1([C:21](Cl)=[O:22])[CH2:20][CH2:19]1.[Cl-]>C(O)(=O)C>[C:6]([NH:5][C:4]1[CH:3]=[C:2]([CH:12]=[CH:11][CH:10]=1)[NH:1][C:21]([CH:18]1[CH2:20][CH2:19]1)=[O:22])(=[O:9])[CH2:7][CH3:8]

参加物

6

反応物 4

HCID 312ChlorideHCID 77637Cyclopropanecarbonyl chlorideHCID 89953N-(3-Aminophenyl)propanamideHCID 517045Sodium Acetate

生成物 1

HCID 17188249N-[3-(propionylamino)phenyl]cyclopropanecarboxamide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Meta-aminopropionanilide, 13.1 g. (0.08 mole) is dissolved in 200 ml. of a 50/50 v/v mixture of glacial acetic acid and saturated sodium acetate solution. To this solution is added 9.2 g. (0.088 moles) of cyclopropane carbonyl chloride. The chloride is added slowly with adequate stirring and cooling. The product, which crystallizes from the solution, is collected by filtration. The product is consecutively washed with a 5 percent solution of sodium hydroxide, a 5 percent solution of hydrochloric acid and water. After washing, the crystals are dried. There is obtained 15 g. (81 percent of theory) of the title compound, m.p. 185°-186° C.

後処理

  1. dissolution(0.08 mole) is dissolved in 200 ml
  2. additionTo this solution is added 9.2 g
  3. temperaturecooling
  4. customThe product, which crystallizes from the solution
  5. filtrationis collected by filtration
  6. washThe product is consecutively washed with a 5 percent solution of sodium hydroxide
  7. washAfter washing
  8. customthe crystals are dried
  9. customThere is obtained 15 g

出典と根拠

ORDレコード
ord-4f74be1ed0ec4c47b00028e01f828779
出典データセット
uspto-grants-1977_06
特許番号
US04028093

反応ノート

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