Ammonia → Methyl 3-(aminosulfonyl)-2-thiophenecarboxylate

HRID 436831

反応式

HRID 436831 の反応式
Cl[S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:4])=[O:3].[NH3:14]>C(Cl)(Cl)Cl>[S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:4])(=[O:3])[NH2:14]

参加物

4

反応物 2

HCID 222AmmoniaHCID 27367332-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester

生成物 1

HCID 101012Methyl 3-(aminosulfonyl)-2-thiophenecarboxylate

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

43.5 g (0.181 mole) of methyl 3-chlorosulfonylthiophene-2-carboxylate (VIII) is dissolved in 450 ml of absolute chloroform; ammonia is passed in at room temperature until the mixture has an alkaline reaction. After stirring the solution for a further 3 hours at room temperature (care being taken to keep the solution alkaline) it is extracted with water and the organic phase is dried and evaporated. The crystalline residue may be recrystallized from ethanol; however, for further reaction digestion with ether is sufficient.

後処理

  1. customis passed in at room temperature until the mixture
  2. customan alkaline reaction
  3. extractionis extracted with water
  4. customthe organic phase is dried
  5. customevaporated
  6. customThe crystalline residue may be recrystallized from ethanol

出典と根拠

ORDレコード
ord-51332c6b1b534fad9c929433efb4889c
出典データセット
uspto-grants-1977_06
特許番号
US04028373

関連ノート

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