Sodium Hydroxide → HCID 54452714、化合物

HRID 436958ノート

反応式

HRID 436958 の反応式
C([O:8][C:9](=[O:55])[C@H:10]([CH2:51][CH:52]([CH3:54])[CH3:53])[NH:11][C:12](=[O:50])[C@H:13]([CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)[NH:14][C:15](=[O:42])[C@H:16]([CH3:41])[NH:17][C:18](=[O:40])[CH2:19][NH:20][C:21](=[O:39])[C@H:22]([CH2:31][C:32]1[CH:37]=[CH:36][C:35]([OH:38])=[CH:34][CH:33]=1)[NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])C1C=CC=CC=1.[OH-].[Na+]>CO>[C:27]([O:26][C:24]([NH:23][C@H:22]([C:21]([NH:20][CH2:19][C:18]([NH:17][C@H:16]([C:15]([NH:14][C@H:13]([C:12]([NH:11][C@H:10]([C:9]([OH:55])=[O:8])[CH2:51][CH:52]([CH3:53])[CH3:54])=[O:50])[CH2:43][C:44]1[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=1)=[O:42])[CH3:41])=[O:40])=[O:39])[CH2:31][C:32]1[CH:33]=[CH:34][C:35]([OH:38])=[CH:36][CH:37]=1)=[O:25])([CH3:28])([CH3:30])[CH3:29]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 54262973HCID 54262973、化合物

生成物 1

HCID 54452714HCID 54452714、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
10 °C

実験手順

18.9 Parts N-t-butoxycarbonyl-L-tyrosylglycyl-L-alanyl-L-phenylalanyl-L-leucine benzyl ester is dissolved in 70 parts methanol and the solution cooled to 10° C. Then, 90 parts by volume of a 1N sodium hydroxide solution is added dropwise with stirring while maintaining the temperature below 20° C. After standing at room temperature for 1 hour, the methanol is removed by evaporation under reduced pressure. The solution is washed once with ethyl ether to remove benzyl alcohol and the aqueous layer acidified with 90 parts by volume of a 1 N hydrochloric acid solution. The solid which results is filtered and washed with water to afford N-t-butoxycarbonyl-L-tyrosylglycyl-L-alanyl-L-phenylalanyl-L-leucine.

後処理

  1. temperaturewhile maintaining the temperature below 20° C
  2. customthe methanol is removed by evaporation under reduced pressure
  3. washThe solution is washed once with ethyl ether
  4. customto remove benzyl alcohol
  5. customThe solid which results
  6. filtrationis filtered
  7. washwashed with water

出典と根拠

ORDレコード
ord-a25e1183125f44359966c2df80989f8c
出典データセット
uspto-grants-1977_06
特許番号
US04028319

反応ノート

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