Trifluoroacetic acid → Trifluoroacetic acid
反応式
[CH2:1]([O:3][C:4](=[O:27])[N:5]([CH3:26])[NH:6][C:7](=[O:25])[C@@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:24])[C@H:14]([CH3:23])[NH:15]C(OC(C)(C)C)=O)[CH3:2].[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>C(Cl)Cl>[CH2:1]([O:3][C:4](=[O:27])[N:5]([CH3:26])[NH:6][C:7](=[O:25])[C@@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:24])[C@H:14]([CH3:23])[NH2:15])[CH3:2].[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]参加物
5
実験手順
To the t-butoxycarbonylalanylprolyl-2-azaalanine ethyl ester obtained above is added 15 ml of methylene chloride. The reaction mixture is cooled to 0° and 15 ml of trifluoroacetic acid added. After stirring for 1 hour at 0° and 1 hour at room temperature, the reaction mixture is concentrated in vacuo to yield alanylprolyl-2-azaalanine ethyl ester as its trifluoroacetic acid salt.