1-Methylpiperazine → 4-(4-Methylpiperazine-1-yl)-3-sulfamoylbenzoic acid-ethylester

HRID 437152ノート

反応式

HRID 437152 の反応式
[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[CH:9][C:8](Cl)=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)[CH3:2].[CH3:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>O>[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[CH:9][C:8]([N:21]2[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]2)=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)[CH3:2]

参加物

4

反応物 2

HCID 531671-MethylpiperazineHCID 15938945Benzoic acid, 3-(aminosulfonyl)-4-chloro-, ethyl ester

生成物 1

HCID 538539394-(4-Methylpiperazine-1-yl)-3-sulfamoylbenzoic acid-ethylester

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

141 Grams of 4-chloro-3-sulfamoylbenzoic acid-ethylester (0.5 mole) were stirred for 1 hour at 110° C. with 250 ml of N-methylpiperazine. The crystalline precipitate obtained after the reaction solution had been poured into 2.0 l of water suction-filtered, was washed with water, dried on the steam bath and recrystallized twice from a mixture of diisopropylether and acetic ester.

後処理

  1. customThe crystalline precipitate obtained after the reaction solution
  2. filtrationsuction-filtered
  3. washwas washed with water
  4. customdried on the steam bath
  5. customrecrystallized twice from a mixture of diisopropylether and acetic ester

出典と根拠

ORDレコード
ord-d838891d499c450ca84a539509a31aaf
出典データセット
uspto-grants-1977_06
特許番号
US04029787

反応ノート

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