[CH2:1]([NH:4][S:5]([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[Cl:17])[C:11]([OH:13])=[O:12])(=[O:7])=[O:6])[CH:2]=[CH2:3].[CH3:18][N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.Cl>CN(C)C=O>[ClH:17].[CH2:1]([NH:4][S:5]([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[N:22]1[CH2:23][CH2:24][N:19]([CH3:18])[CH2:20][CH2:21]1)[C:11]([OH:13])=[O:12])(=[O:7])=[O:6])[CH:2]=[CH2:3]A mixture of 28 g of 3-allylsulfamoyl-4-chlorobenzoic acid, 30 g of N-methylpiperazine and 20 ml of dimethylformamide was heated for 4 hours at 140° C. When the reaction solution was subsequently introduced into 0.3 l of 2N HCl, the monohydrochloride crystallized immediately. The product was then purified by recrystallization from water.
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