N-Pyridin-4-ylacetamide → 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-acetamidopyridinium iodide

HRID 437213

反応式

HRID 437213 の反応式
[I:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([O:12][CH3:13])[CH:5]=1.[C:14]([NH:17][C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1)(=[O:16])[CH3:15]>C(O)C>[I-:1].[CH3:13][O:12][C:6]1[CH:5]=[C:4]([CH2:3][CH2:2][N+:21]2[CH:22]=[CH:23][C:18]([NH:17][C:14](=[O:16])[CH3:15])=[CH:19][CH:20]=2)[CH:9]=[CH:8][C:7]=1[O:10][CH3:11]

参加物

4

反応物 2

HCID 21288N-Pyridin-4-ylacetamideHCID 5970224-(2-Iodoethyl)-1,2-dimethoxybenzene

生成物 1

HCID 214132591-[2-(3,4-Dimethoxyphenyl)ethyl]-4-acetamidopyridinium iodide収率 67.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1-(2-Iodoethyl)-3,4-dimethoxybenzene (29.3 g.) and 4-acetamidopyridine (14.0 g.) in absolute ethanol (100 ml.) were refluxed for 2.5 hours. The resulting crystalline material was collectd and recrystallised from ethanol to give the title compound (29.1 g.), m.p. 201°-202° C. (Found: C, 47.9; H, 4.9; N, 6.3; C17H21IN2O3 requires C, 47.7; H, 4.9; N, 6.5%).

後処理

  1. customrecrystallised from ethanol

出典と根拠

ORDレコード
ord-12080977457145908188d689a8d8b499
出典データセット
uspto-grants-1977_06
特許番号
US04029801

関連ノート

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