2-Naphthaleneethanol → 4-Benzamido-1-[2-(2-naphthyl)ethyl]piperidine

HRID 437246

反応式

HRID 437246 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][CH2:12]O.[C:14]([NH:22][CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>[Ni].C1(C)C(C)=CC=CC=1>[C:14]([NH:22][CH:23]1[CH2:28][CH2:27][N:26]([CH2:12][CH2:11][C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)[CH2:25][CH2:24]1)(=[O:21])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

参加物

5

反応物 2

HCID 738772-NaphthaleneethanolHCID 118120N-4-Piperidylbenzamide

生成物 1

HCID 214306134-Benzamido-1-[2-(2-naphthyl)ethyl]piperidine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 7237O-Xylene溶媒

実験手順

2-(2-Naphthyl)ethanol (3.44 g., 0.02 mole), 4-benzamidopiperidine (4.08 g., 0.02 mole) and Raney Nickel (W7 ca. 5 g.) were suspended in xylene (200 ml.) and the stirred mixture boiled under reflux for 16 hours. Liberated water was removed by means of a Dean and Stark apparatus. The mixture was filtered hot and evaporated to ca. 100 ml. The resulting yellow solution was stored until crystallisation was complete. The title compound was obtained as off-white needles (3.30 g.), m.p. 189°-191° C.

後処理

  1. temperatureunder reflux for 16 hours
  2. customLiberated water was removed by means of a Dean and Stark apparatus
  3. filtrationThe mixture was filtered hot
  4. customevaporated to ca. 100 ml
  5. customThe resulting yellow solution was stored until crystallisation

出典と根拠

ORDレコード
ord-f0ae86a5d7d94fe7a08083e5cbbad43a
出典データセット
uspto-grants-1977_06
特許番号
US04029801

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