Methyl iodide → HCID 21430644、化合物
反応式
[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:20])[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:27][CH3:28]>CN(C)C=O>[I-:27].[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][N+:13]([CH3:28])([CH2:16][CH2:17][CH2:18][C:19]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:20])[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
A solution of 4-benzamido-1-(4-phenyl-4-oxobutyl)-piperidine (1.75 g., 0.005 mole) and iodomethane (7.10 g., 0.05 mole) in N,N-dimethylformamide (5 ml.) was stirred for 150 hours at room temperature. The reaction mixture was filtered and the residue was washed with fresh N,N-dimethylformamide and then diethyl ether.
後処理
- filtrationThe reaction mixture was filtered