4-Chlorobenzoyl chloride → 4-Chlorobenzoic N2-(4-nitrophenyl)hydrazide

HRID 437300

反応式

HRID 437300 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][NH2:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[Cl:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](Cl)=[O:18])=[CH:15][CH:14]=1>C(#N)C>[Cl:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([NH:11][NH:10][C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)=[O:18])=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 85014-Chlorobenzoyl chlorideHCID 3310889(4-Nitrophenyl)hydrazine

生成物 1

HCID 31065344-Chlorobenzoic N2-(4-nitrophenyl)hydrazide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

反応条件

温度
0 °C

実験手順

4-Nitrophenylhydrazine (32.0 g, 0.21 mole) was slurried in acetonitrile (500 ml) and the mixture was cooled to 0° C. A solution of 4-chlorobenzoyl chloride (17.5 g, 0.10 mole) in acetonitrile (25 ml) was added dropwise to the cooled slurry. The reaction mixture was allowed to stand overnight. The mixture was filtered and the solid was washed with acetonitrile, then thoroughly with water. The product was recrystallized from acetonitrile and decolorized with charcoal to give a pale yellow solid. Yield 24.8 g (85%) m.p. 245.5°-248.5° C.

後処理

  1. filtrationThe mixture was filtered
  2. washthe solid was washed with acetonitrile
  3. customThe product was recrystallized from acetonitrile
  4. customto give a pale yellow solid

出典と根拠

ORDレコード
ord-dcc1940639ff4d9292a6efc96f2e2c56
出典データセット
uspto-grants-1977_06
特許番号
US04030925

関連ノート

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