2-Amino-5-methyl-7-pentafluoroethyl-1,8-naphthyridine → HCID 21428391、化合物
反応式
N[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[N:5][C:6]([C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15])=[CH:7][C:8]=2[CH3:12])[N:3]=1.N([O-])=[O:21].[Na+]>FC(F)(F)C(O)=O>[CH3:12][C:8]1[CH:7]=[C:6]([C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15])[N:5]=[C:4]2[C:9]=1[CH:10]=[CH:11][C:2](=[O:21])[NH:3]2参加物
4
実験手順
2-Amino-5-methyl-7-pentafluoroethyl-1,8-naphthyridine (5.54 g., 20 mmole) is dissolved in trifluoroacetic acid (40 ml.) and to the stirred solution cooled to -5° to 0° C. is added finely powdered sodium nitrite (3.0 g., 43.5 mmole) in small portions. Stirring of the mixture is continued at room temperature for one hour, after which it is poured into ice-water (ca. 500 ml.). The product precipitates and is collected, washed and dried at 60° C. in air. It can be purified by recrystallization from diisopropyl ether.