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4-Chlorobenzhydryl chloride → 1-(p-Chlorophenyl-phenylmethyl)-3-methyl-3-(3,4-dimethoxybenzyl)-piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorobenzhydryl chloride | HCID 241584 | — |
| 反応物 | HCID 20363969 | HCID 20363969 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | 1-(p-Chlorophenyl-phenylmethyl)-3-methyl-3-(3,4-dimethoxybenzyl)-piperazine | HCID 21428573 | 80% |
反応手順
If 3-methyl-3-(3,4-dimethoxybenzyl)-piperazine is reacted with p-chlorophenyl-phenylmethyl chloride in methyl ethyl ketone according to Example 2, 1-(p-chlorophenyl-phenylmethyl)-3-methyl-3-(3,4-dimethoxybenzyl)-piperazine is obtained in 80 percent yield after a 12-hour reaction period. The hydrochloride has a melting point of 235°-237° C. (isopropanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04031216 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-0e0fbab6d28e43e39ecb27d785c875e3 |
| 出典メモ | uspto-grants-1977_06 |