2-Fluorotoluene → 1-Benzyl-4-(o-tolyloxy)piperidine

反応式

[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.F[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH3:22]>>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

反応物 2

HCID 72412-Fluorotoluene

HCID 784611-Benzylpiperidin-4-ol

生成物 1

HCID 214287021-Benzyl-4-(o-tolyloxy)piperidine

実験手順

By following the manipulative procedure described in Example 1(a), 21.0 g of 1-benzyl-4-piperidinol and 24.0 g of o-fluorotoluene produces a yellow oil fraction which boils at 161°-163° C., 0.09 mm. This oil solidifies slowly upon standing and is recrystallized from petroleum ether (b.p. 30°-60°) to give white crystals of 1-benzyl-4-(o-tolyloxy) piperidine.

後処理

customproduces a yellow oil fraction which boils at 161°-163° C., 0.09 mm
customis recrystallized from petroleum ether (b.p. 30°-60°)

出典と根拠

ORDレコード: ord-37c52c96522c47929cc932db7d422f4b
出典データセット: uspto-grants-1977_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04031221

反応ノート

読み込み中…

参加物