Thionyl Chloride → 4-Fluoro-2-nitrobenzoyl chloride

HRID 437619ノート

反応式

HRID 437619 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1.S(Cl)([Cl:16])=O>C1C=CC=CC=1>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:16])=[O:7])=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 27374164-Fluoro-2-nitrobenzoic acid

生成物 1

HCID 133524084-Fluoro-2-nitrobenzoyl chloride

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a stirred mixture of 76 parts of 4-fluoro-2-nitrobenzoic acid and 225 parts of benzene are added dropwise 71 parts of sulfinyl chloride. Upon completion, stirring is continued first for 5 hours at reflux and further overnight at room temperatue. The reaction mixture is evaporated. The residue is taken up twice in benzene and the latter is evaporated each time, yielding 85 parts of 4-fluoro-2-nitrobenzoyl chloride as a residue.

後処理

  1. temperatureat reflux and further overnight at room temperatue
  2. customThe reaction mixture is evaporated
  3. customthe latter is evaporated each time

出典と根拠

ORDレコード
ord-f6d8aff7fb8f461c8cfc83818fd92f64
出典データセット
uspto-grants-1977_06
特許番号
US04031226

反応ノート

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