Diisopropylethylamine → Methyl cis(+/-)-6-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-3-carboxylate

HRID 43765ノート

反応式

HRID 43765 の反応式
Cl.[Cl:2][C:3]1[N:4]=[C:5]([C:10]([NH:12][C@H:13]2[CH2:18][CH2:17][NH:16][CH2:15][C@H:14]2[O:19][CH3:20])=[O:11])[NH:6][C:7]=1[CH2:8][CH3:9].F[C:22]1[N:27]=[CH:26][C:25]([C:28]([O:30][CH3:31])=[O:29])=[CH:24][CH:23]=1.C(N(C(C)C)CC)(C)C>>[Cl:2][C:3]1[N:4]=[C:5]([C:10]([NH:12][C@H:13]2[CH2:18][CH2:17][N:16]([C:22]3[N:27]=[CH:26][C:25]([C:28]([O:30][CH3:31])=[O:29])=[CH:24][CH:23]=3)[CH2:15][C@H:14]2[O:19][CH3:20])=[O:11])[NH:6][C:7]=1[CH2:8][CH3:9]

参加物

4

反応物 3

HCID 81531DiisopropylethylamineHCID 13758765Methyl 6-fluoropyridine-3-carboxylateHCID 86648695cis(+/-)-4-Chloro-5-ethyl-N-(3-methoxypiperidin-4-yl)-1H-imidazole-2-carboxamide hydrochloride

生成物 1

HCID 86648713Methyl cis(+/-)-6-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-3-carboxylate収率 96.3%

実験手順

The same operation as in Example (158a) was performed using cis(±)-4-chloro-5-ethyl-N-(3-methoxypiperidin-4-yl)-1H-imidazole-2-carboxamide hydrochloride obtained in Example (159a) (104 mg, 0.32 mmol), methyl 6-fluoropyridine-3-carboxylate (50 mg, 0.32 mmol) and diisopropylethylamine (125 mg, 0.97 mmol), to obtain 130 mg of the title compound as a yellow brown oily substance (96%).

出典と根拠

ORDレコード
ord-69ffbeec14144d059014998650e22bd6
出典データセット
uspto-grants-2013_09
特許番号
US08536197B2

反応ノート

読み込み中…