Ethanolamine → N-(2-Hydroxyethyl)picolinamide

HRID 437650

反応式

HRID 437650 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([O:9]C)=O.[NH2:11][CH2:12][CH2:13][OH:14]>>[OH:14][CH2:13][CH2:12][NH:11][C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:9]

参加物

3

反応物 2

HCID 700EthanolamineHCID 755692-Carbomethoxypyridine

生成物 1

HCID 2045999N-(2-Hydroxyethyl)picolinamide

実験手順

A mixture of 72 parts of methyl 2-pyridinecarboxylate and 32 parts of 2-aminoethanol is stirred and refluxed carefully for 2 hours. The reaction mixture is cooled and poured onto water. The product is extracted five times with trichloromethane. The combined extracts are dried, filtered and evaporated, yielding 49 parts of N-(2-hydroxyethyl)-2-pyridinecarboxamide as a residue.

後処理

  1. temperaturerefluxed carefully for 2 hours
  2. temperatureThe reaction mixture is cooled
  3. additionpoured onto water
  4. extractionThe product is extracted five times with trichloromethane
  5. customThe combined extracts are dried
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-5704bb8efb124950a0793cacfb9bcc3f
出典データセット
uspto-grants-1977_06
特許番号
US04031226

関連ノート

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