Dicyclohexylcarbodiimide → Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alanine methyl ester

関与物質

役割	名称	HCID	仕込み量
反応物	Dicyclohexylcarbodiimide	HCID 10868	—
反応物	N-tert-Butoxycarbonyl-L-tryptophan	HCID 83169	—
反応物	L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-	HCID 90234	—
反応物	BOC-D-alanine	HCID 637606	—
反応物	Boc-D-Tyr(Bzl)-Oh	HCID 6992575	—
生成物	Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alanine methyl ester	HCID 54340573	—

反応手順

Nα-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alanine resin is obtained according to the procedure of Example 1 by treating 20 g. of Nα-t-butoxycarbonyl-D-alanine resin, 0.0132 mol, with 7.4 g., 0.02 mol, of Nα-t-butoxycarbonyl-O-benzyl-D-tyrosine and 4.1 g., 0.02 mol, of dicyclohexylcarbodiimide, (2) 6.0 g., 0.02 mol, of Nα-t-butoxycarbonyl-O-benzyl-L-serine and 4.1 g. of dicyclohexylcarbodiimide, and (3) 6.1 g. of Nα-t-butoxycarbonyl-L-tryptophan and 4.1 g. of dicyclohexylcarbodiimide.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US04031069
出典データセット	uspto-grants-1977_06
ORD ID	ord-a241e9b4db8e44bd8139d5072b78c7cf
出典メモ	uspto-grants-1977_06