Dicyclohexylcarbodiimide → Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-valine

HRID 437692

反応式

HRID 437692 の反応式
C(OC([NH:8][C@@H:9]([C:13]([OH:15])=[O:14])[CH:10]([CH3:12])[CH3:11])=O)(C)(C)C.C(O[C:21]([NH:23][C@H:24]([C:40]([OH:42])=O)[CH2:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[CH:28][CH:27]=1)=[O:22])(C)(C)C.C1(N=C=NC2CCCCC2)CCCCC1.C(O[C:63]([NH:65][C@H:66](C(O)=O)[CH2:67][O:68][CH2:69][C:70]1[CH:75]=[CH:74][CH:73]=[CH:72][CH:71]=1)=[O:64])(C)(C)C.[C:79]([O:83][C:84]([NH:86][C@H:87](C(O)=O)[CH2:88][C:89]1[C:97]2[C:92](=[CH:93][CH:94]=[CH:95][CH:96]=2)[NH:91][CH:90]=1)=[O:85])([CH3:82])([CH3:81])[CH3:80]>>[C:79]([O:83][C:84]([NH:86][C@H:87]([C:63]([NH:65][C@H:66]([C:21]([NH:23][C@H:24]([C:40]([NH:8][C@@H:9]([C:13]([OH:15])=[O:14])[CH:10]([CH3:12])[CH3:11])=[O:42])[CH2:25][C:26]1[CH:27]=[CH:28][C:29]([O:32][CH2:33][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)=[CH:30][CH:31]=1)=[O:22])[CH2:67][O:68][CH2:69][C:70]1[CH:71]=[CH:72][CH:73]=[CH:74][CH:75]=1)=[O:64])[CH2:88][C:89]1[C:97]2[C:92](=[CH:93][CH:94]=[CH:95][CH:96]=2)[NH:91][CH:90]=1)=[O:85])([CH3:80])([CH3:81])[CH3:82]

参加物

6

反応物 5

HCID 10868Dicyclohexylcarbodiimide3 回HCID 83169N-tert-Butoxycarbonyl-L-tryptophanHCID 90234L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-HCID 98763O-benzyl-N-((tert-butoxy)carbonyl)-L-tyrosineHCID 637605(2R)-2-(((tert-butoxy)carbonyl)amino)-3-methylbutanoic acid

生成物 1

HCID 53678011Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-valine

実験手順

Nα-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-valine resin is prepared according to the procedure of Example 1 from Nα-t-butoxycarbonyl-D-valine resin, 11 g., 5 mmol, reacted successively with (1) 3.5 g., 9.4 mmol, of Nα-t-butoxycarbonyl-O-benzyl-L-tyrosine and 2 g., 9.7 mmol, of dicyclohexylcarbodiimide, (2) 3 g., 9.8 mmol, of Nα-t-butoxycarbonyl-O-benzyl-L-serine and 2 g. of dicyclohexylcarbodiimide and (3) 3 g., 9.85 mmol, of Nα-t-butoxycarbonyl-L-tryptophan and 2 g. of dicyclohexylcarbodiimide.

出典と根拠

ORDレコード
ord-1a651dfc146d4c0fa3cec0dec8da3974
出典データセット
uspto-grants-1977_06
特許番号
US04031069

関連ノート

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