Dicyclohexylcarbodiimide → Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-valine

関与物質

役割	名称	HCID	仕込み量
反応物	Dicyclohexylcarbodiimide	HCID 10868	—
反応物	N-tert-Butoxycarbonyl-L-tryptophan	HCID 83169	—
反応物	L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-	HCID 90234	—
反応物	O-benzyl-N-((tert-butoxy)carbonyl)-L-tyrosine	HCID 98763	—
反応物	(2R)-2-(((tert-butoxy)carbonyl)amino)-3-methylbutanoic acid	HCID 637605	—
生成物	Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-valine	HCID 53678011	—

反応手順

Nα-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-valine resin is prepared according to the procedure of Example 1 from Nα-t-butoxycarbonyl-D-valine resin, 11 g., 5 mmol, reacted successively with (1) 3.5 g., 9.4 mmol, of Nα-t-butoxycarbonyl-O-benzyl-L-tyrosine and 2 g., 9.7 mmol, of dicyclohexylcarbodiimide, (2) 3 g., 9.8 mmol, of Nα-t-butoxycarbonyl-O-benzyl-L-serine and 2 g. of dicyclohexylcarbodiimide and (3) 3 g., 9.85 mmol, of Nα-t-butoxycarbonyl-L-tryptophan and 2 g. of dicyclohexylcarbodiimide.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US04031069
出典データセット	uspto-grants-1977_06
ORD ID	ord-1a651dfc146d4c0fa3cec0dec8da3974
出典メモ	uspto-grants-1977_06