Hydrochloric Acid → HCID 23336006、化合物

HRID 437728ノート

反応式

HRID 437728 の反応式
[NH2:1][C:2]1[S:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].[CH3:13][N:14]=[C:15]=[O:16].Cl>N1C=CC=CC=1>[CH2:11]([O:10][C:8]([C:3]1[C:4]([CH3:7])=[N:5][S:6][C:2]=1[NH:1][C:15]([NH:14][CH3:13])=[O:16])=[O:9])[CH3:12]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 12228Methyl IsocyanateHCID 2820511ethyl 5-amino-3-methylisothiazole-4-carboxylate

生成物 1

HCID 23336006HCID 23336006、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
80 °C

実験手順

A solution of 5-amino-4-ethoxycarbonyl-3-methylisothiazole (prepared by the method of Goerdeler and Horn, op cit; 3.72 g.) in pyridine (10 ml.) was treated at 80° C. with methyl isocyanate (1.5 ml.) and the mixture was maintained at 80° C. for 6 hours. The mixture was then poured into an excess of dilute aqueous hydrochloric acid to give an off-white precipitate which was filtered off and recrystallised from ethanol to give colourless crystals of 1-(4-ethoxycarbonyl-3-methylisothiazol-5-yl)-3-methylurea (1.6 g.), m.p. 191°-193° C.

後処理

  1. customto give an off-white precipitate which
  2. filtrationwas filtered off
  3. customrecrystallised from ethanol

出典と根拠

ORDレコード
ord-0224fe3a24b54ea69e351b98e9e2d980
出典データセット
uspto-grants-1977_06
特許番号
US04032323

反応ノート

読み込み中…