2-Amino-3-hydroxybutanoic acid → N-(2,3,4,5,6-pentahydroxy-hexyl)-DL-threonine

HRID 438005

反応式

HRID 438005 の反応式
O=[CH:2][C@@H:3]([C@H:5]([C@@H:7]([C@@H:9]([CH2:11][OH:12])[OH:10])[OH:8])[OH:6])[OH:4].[NH2:13][CH:14]([C:18]([OH:20])=[O:19])[CH:15]([CH3:17])[OH:16].CO>[Ni].[Pd].O>[OH:4][CH:3]([CH:5]([OH:6])[CH:7]([OH:8])[CH:9]([OH:10])[CH2:11][OH:12])[CH2:2][NH:13][CH:14]([C:18]([OH:20])=[O:19])[CH:15]([CH3:17])[OH:16]

参加物

7

反応物 3

HCID 2052-Amino-3-hydroxybutanoic acidHCID 887MethanolHCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal

生成物 1

HCID 21427714N-(2,3,4,5,6-pentahydroxy-hexyl)-DL-threonine

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 23938Palladium触媒HCID 962Water溶媒

実験手順

The starting materials were D-glucose and DL-threonine. The reductive amination was carried out using Raney nickel or palladium/activated carbon (10%) and yielded a product having a melting point of 219° C. (decomposition) and a RF -value of 0.67 (determined on DC-finished plates of silica gel G (Merck) with a transporting fluid made up of 75 parts by volume of methanol and 25 parts by volume of water).

後処理

  1. customyielded a product

出典と根拠

ORDレコード
ord-0045e3d370ba48e49958eaef34400e88
出典データセット
uspto-grants-1977_06
特許番号
US04032676

関連ノート

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