Staurosporine → Biphenyl

HRID 438033

反応式

HRID 438033 の反応式
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4.N#Cc1ccc(C=O)cc1Br>CC(=O)N(C)C.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].[Na+].[Ti+4]>CO[C@@H]1[C@H](N(C)Cc2ccc(C#N)c(Br)c2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4

参加物

10

反応物 2

HCID 44259StaurosporineHCID 534255192-Bromo-4-formylbenzonitrile

生成物 4

HCID 7095BiphenylHCID 44259StaurosporineHCID 2884342-Bromo-4-(hydroxymethyl)benzonitrileHCID 178496679HCID 178496679、化合物

試薬・触媒・溶媒 4

HCID 176Acetic Acid試薬HCID 11026Titanium isopropoxide試薬HCID 5049666Sodium triacetoxyborohydride試薬HCID 31374Dimethylacetamide溶媒7 回

反応条件

温度
22 °C

後処理

  1. additionThe next morning, the Mosquito(R) was used to dilute the 100 mM reactions to 50 mM via addition of 1 uL DMSO to each reaction well, followed by dispense mixing.
  2. additionThe reactions were diluted with 3x1 uL DMSO (containing PhPh as an internal standard) using the Mosquito(R). The reactions were mixed after each dispense operation.
  3. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis by UPLC.
  4. additionMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis by UPLC.

出典と根拠

ORDレコード
ord-6159d1a90187472bb0285fa0b9da0e71
出典データセット
Cernak miniaturized reductive amination
元リンク
出典を表示

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