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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
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Staurosporine → Biphenyl

HRID 438252
ノート
印刷プレビュー

反応式

HRID 438252 の反応式
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4.O=C1CCN(c2ccc(F)c(F)c2)CC1>CC(=O)N(C)C.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].[Na+].[Ti+4]>CO[C@@H]1[C@H](N(C)C2CCN(c3ccc(F)c(F)c3)CC2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
参加物反応条件後処理出典と根拠反応ノート

参加物

10

反応物 2

HCID 44259StaurosporineHCID 246938011-(3,4-Difluorophenyl)piperidin-4-one

生成物 4

HCID 7095BiphenylHCID 44259StaurosporineHCID 10727303HCID 10727303、化合物HCID 178496665HCID 178496665、化合物

試薬・触媒・溶媒 4

HCID 176Acetic Acid試薬HCID 11026Titanium isopropoxide試薬HCID 5049666Sodium triacetoxyborohydride試薬HCID 31374Dimethylacetamide溶媒7 回

反応条件

温度
22 °C

後処理

  1. additionThe next morning, the Mosquito(R) was used to dilute the 100 mM reactions to 50 mM via addition of 1 uL DMSO to each reaction well, followed by dispense mixing.
  2. additionThe reactions were diluted with 3x1 uL DMSO (containing PhPh as an internal standard) using the Mosquito(R). The reactions were mixed after each dispense operation.
  3. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis by UPLC.
  4. additionMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis by UPLC.

出典と根拠

ORDレコード
ord-f1fa46a03218408faada9bc526ee548d
出典データセット
Cernak miniaturized reductive amination
DOI
10.1038/s44160-023-00351-1
元リンク
出典を表示

反応ノート

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