Methylamine → HCID 54563804、化合物
反応式
[C:1]([CH:3]([NH:9][C:10]([C:12]1[S:16][C:15](Br)=[N:14][C:13]=1[CH2:18][CH3:19])=[O:11])[C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[CH2:20]([N:22](CC)CC)C.CN>O1CCCC1>[C:1]([CH:3]([NH:9][C:10]([C:12]1[S:16][C:15]([NH:22][CH3:20])=[N:14][C:13]=1[CH2:18][CH3:19])=[O:11])[C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)#[N:2]参加物
5
実験手順
1.0g of 2-bromo-4-ethyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide, 0.40ml of triethylamine and 0.58ml of methylamine were added to 10ml of tetrahydrofuran. The reaction mixture was stirred under reflux for 4 hours and then treated according to the same procedure as EXAMPLE 10 to obtain 0.77g (Yield 89%) of the title compound.
後処理
- temperatureunder reflux for 4 hours
- additiontreated
出典と根拠
- ORDレコード
- ord-0b228e9c16a649b7b2ca49ad1123a086
- 出典データセット
- uspto-grants-1996_05
- 特許番号
- US05514643
反応ノート
読み込み中…