Hydrochloric Acid → HCID 67764133、化合物
反応式
[NH2:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][C:8]([F:14])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[ClH:15]>[Pd]>[ClH:15].[ClH:15].[NH2:1][C:2]1[C:10]([NH2:11])=[CH:9][C:8]([F:14])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]参加物
4
実験手順
A pressure flask capable of withstanding 150 psi. was added 2-amino-5-fluoro-3-nitrobenzoic acid (1.0 g, 5.0 mmol) dissolved in 6M hydrochloric acid (40 mL) and 10% palladium on carbon (100 mg). The reaction was placed in a Parr apparatus and the flask flushed three times with hydrogen leaving an internal pressure of 65 psi. The reaction was continued for 16 hours while maintaining a pressure of 65 psi. The reaction was filtered through celite, washed with cold water and the filtrate evaporated to dryness to give 2,3-diamino-5-fluorobenzoic acid dihydrochloride (962 mg, 79%) as a light brown solid.
後処理
- customA pressure flask capable of withstanding
- customthe flask flushed three times with hydrogen leaving an internal pressure of 65 psi
- temperaturewhile maintaining a pressure of 65 psi
- filtrationThe reaction was filtered through celite
- washwashed with cold water
- customthe filtrate evaporated to dryness
出典と根拠
- ORDレコード
- ord-c5943905d8644d9883646609595c006f
- 出典データセット
- uspto-grants-1996_05
- 特許番号
- US05514676
反応ノート
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