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1,3-Dithiolane → Diethylether ethylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Dithiolane | HCID 20970 | — |
| 反応物 | N-(3-Aminopropyl)morpholine | HCID 61055 | — |
| 反応物 | Ph2CHCO-Leu-Phe-COOEt | HCID 131719396 | — |
| 生成物 | Diethylether ethylacetate | HCID 21584169 | 20% |
反応手順
This compound was synthesized from 1,3-dithiolane derivative of Ph2CHCO-Leu-Phe-COOEt and N-aminopropylmorpholine, and purified by column chromatography using AcOEt followed by crystallization from AcOEt/ether (20% yield). Yellow solid, single spot on TLC, Rf =0.45 (AcOET/CH3OH 9:1), mp 158°-160° C. 1H NMR (CDCl3) ok, MS (FAB) m/e=627 (M+1). Anal: calcd. for C37H46N4O5, 626; C, 70.90; H, 7.40; N, 8.94. Found, C, 70.05; H, 7.43; N, 8.68.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05514694 |
| 出典データセット | uspto-grants-1996_05 |
| ORD ID | ord-a0c4a16670544afa9b01d20d786d28fa |
| 出典メモ | uspto-grants-1996_05 |