Hydrochloric Acid → 2-Cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid

HRID 439561ノート

反応式

HRID 439561 の反応式
[OH-].[Na+].[C:3]([CH2:5][C:6]([OH:8])=[O:7])#[N:4].[OH:9][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][C:17]=1[OH:18])[CH:13]=O.Cl>>[C:3]([C:5](=[CH:13][C:12]1[CH:15]=[CH:16][C:17]([OH:18])=[C:10]([OH:9])[CH:11]=1)[C:6]([OH:8])=[O:7])#[N:4]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 87683,4-DihydroxybenzaldehydeHCID 9740Cyanoacetic acidHCID 14798Sodium Hydroxide

生成物 1

HCID 20542-Cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid

実験手順

To 2N aqueous sodium hydroxide solution (175 ml, 350 mmol) heated at 60° C. were added cyanoacetic acid (7.2 g, 86.7 mmol) and 3, 4-dihydroxybenzaldehyde (12.0 g, 86.9 mmol), and the resulting mixture was stirred for 30 minutes. The reaction mixture was allowed to cool at room temperature and gradually mixed with dilute hydrochloric acid until the reaction mixture became acidic. The product was filtered and dried to give α-cyano-3, 4-dihydroxycinnamic acid (hereinafter referred to as "Compound A" (10.0 g, 56% in yield).

後処理

  1. filtrationThe product was filtered
  2. customdried

出典と根拠

ORDレコード
ord-83702e63595e4e26b6951b6bf4ae4186
出典データセット
uspto-grants-1996_05
特許番号
US05514711

反応ノート

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