Ethanol → 5-bromo-2-butyl-1H-imidazole-4-methanol

HRID 439607ノート

反応式

HRID 439607 の反応式
[Br:1]N1C(=O)CCC1=O.[CH2:9]([C:13]1[NH:14][C:15]([CH2:20][OH:21])=[C:16](CO)[N:17]=1)[CH2:10][CH2:11][CH3:12].C(O)C>O1CCOCC1>[CH2:9]([C:13]1[NH:14][C:15]([CH2:20][OH:21])=[C:16]([Br:1])[N:17]=1)[CH2:10][CH2:11][CH3:12]

参加物

5

反応物 3

HCID 702EthanolHCID 67184N-bromobutanimideHCID 15338146(2-butyl-1H-imidazole-4,5-diyl)dimethanol

生成物 1

HCID 99915715-bromo-2-butyl-1H-imidazole-4-methanol

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

3.56 Grams (20 mmol) of the N-bromosuccinimide was added to a solution consisting of 3.68 g (20.0 mmol) of the 2-butyl-4,5-bis(hydroxymethyl) imidazole, 40 ml of ethanol and 15 ml of dioxane maintained at a temperature of 45° to 50° C. with stirring. The mixture was further reacted at the same temperature for 30 minutes with stirring, and then the solvent was distilled off under reduced pressure. The obtained reaction product was washed with water and was recrystallized from acetonitrile to obtain a pale yellowish scale-like crystalline 2-butyl-4-bromo-5-(hydroxymethyl) imidazole in an amount of 2.36 g (yield, 51%).

後処理

  1. temperaturemaintained at a temperature of 45° to 50° C.
  2. customThe mixture was further reacted at the same temperature for 30 minutes
  3. stirringwith stirring
  4. distillationthe solvent was distilled off under reduced pressure
  5. customThe obtained reaction product
  6. washwas washed with water
  7. customwas recrystallized from acetonitrile

出典と根拠

ORDレコード
ord-025b73636d7a460a9c2331cb9ff512a5
出典データセット
uspto-grants-1996_05
特許番号
US05514811

反応ノート

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