Benzoic acid, 4-ethyl-, methyl ester → Methyl 4-(1-bromoethyl)benzoate

HRID 439795

反応式

HRID 439795 の反応式
[CH2:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][CH:4]=1)[CH3:2].[Br:13]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C1C(C(OOOC(=O)C2C=CC=CC=2)=O)=CC=CC=1>[Br:13][CH:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][CH:4]=1)[CH3:2]

参加物

5

反応物 2

HCID 23827Benzoic acid, 4-ethyl-, methyl esterHCID 67184N-bromobutanimide

生成物 1

HCID 12342351Methyl 4-(1-bromoethyl)benzoate収率 109.2%

試薬・触媒・溶媒 2

HCID 53400210Perbenzoic anhydride触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

To a solution of methyl 4-ethylbenzoate (5.12 g) in carbon tetrachloride (50 ml) were added perbenzoic anhydride (0.20 g) and N-bromosuccinimide (6.07 g) in turn, and the mixture was heated and refluxed. After 30 minutes, the mixture was allowed to cool, and the precipitate was separated by filtration, and washed with carbon tetrachloride. The filtrate and the washings were combined, and concentrated under reduced pressure to give the title compound (8.28 g)

後処理

  1. temperaturethe mixture was heated
  2. temperaturerefluxed
  3. temperatureto cool
  4. customthe precipitate was separated by filtration
  5. washwashed with carbon tetrachloride
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-6752eb1d056948a78eb8c05cb67c60e2
出典データセット
uspto-grants-1996_05
特許番号
US05516777

関連ノート

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