Bromine → 2-Bromo-1-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one

HRID 4403

反応式

HRID 4403 の反応式
[C:1]([C:4]1[N:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:7][C:8]=1[CH3:9])(=[O:3])[CH3:2].[Br:16]Br.C(=O)(O)[O-].[Na+]>C(Cl)(Cl)Cl>[Br:16][CH2:2][C:1]([C:4]1[N:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:7][C:8]=1[CH3:9])=[O:3]

参加物

5

反応物 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 123378491-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one

生成物 1

HCID 149136502-Bromo-1-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one収率 86.8%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

反応条件

温度
55 °C

実験手順

To a stirred solution of 4-acetyl-5-methyl-2-phenyloxazole (12.0 g) in chloroform (100 ml) was added at 50° C. a solution of bromine (10.5 g) in chloroform (10 ml). The mixture was further heated at 55° C. for 30 minutes and poured into saturated aqueous sodium bicarbonate solution (500 ml). The chloroform layer was separated and the aqueous layer was extracted with chloroform. The conbined chloroform layer was washed with water and dried (MgSO4). Evaporation of the solvent gave 4-bromoacetyl-5-methyl-2-phenyloxazole as crystals (14.5 g, 86.3%). Recrystallization from ethyl ether-hexane gave colorless rods, mp 88°-89° C.

後処理

  1. customThe chloroform layer was separated
  2. extractionthe aqueous layer was extracted with chloroform
  3. washThe conbined chloroform layer was washed with water
  4. dry with materialdried (MgSO4)
  5. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-fa6b00b25d154a97988b043a2abfac3a
出典データセット
uspto-grants-1988_02
特許番号
US04725610

関連ノート

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