1,1-Dibromoethane → 4-(2-(Tetrahydropyran-2-yloxy)ethyl)phenethyl alcohol

HRID 440468ノート

反応式

HRID 440468 の反応式
[Mg].[O:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[O:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14](Br)=[CH:13][CH:12]=1.BrC(Br)C.[CH2:22]1[O:24][CH2:23]1.O1CCCC1>O1CCCC1.O>[O:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[O:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:22][CH2:23][OH:24])=[CH:13][CH:12]=1

参加物

7

反応物 4

HCID 112011,1-DibromoethaneHCID 5462224MagnesiumHCID 133067582-(4-bromophenethoxy)tetrahydro-2H-pyranHCID 21868110Ethylene oxide tetrahydrofuran

生成物 1

HCID 542369074-(2-(Tetrahydropyran-2-yloxy)ethyl)phenethyl alcohol収率 48.8%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Magnesium (1.31 g, 53.90 mmol) was added to a solution of 4-(2-(tetrahydropyran-2-yloxy)ethyl)bromobenzene (14.00 g, 49.09 mmol) in tetrahydrofuran (20 ml). Then dibromoethane (0.1 ml) was added under an atmosphere of nitrogen gas, and the mixture was stirred under room temperature for 1 hour. After cooling to ice-cooling temperature, 2M-ethylene oxide/tetrahydrofuran solution (49.09 ml, 98.18 mmol) was added, and the mixture was stirred at room temperature for 2 hours. Then, water (40 ml) was added to the reaction mixture. The mixture was extracted with ethyl ether and dried over magnesium sulfate. After evaporation of the solvent, the residue was purified by column chromatography on silica gel eluting with n-hexane/ethyl acetate (=8/2) to give the desired 4-(2-(tetrahydropyran-2-yloxy)ethyl)phenethyl alcohol (6.00 g, 42%) .

後処理

  1. temperatureAfter cooling to ice-
  2. additionwas added
  3. stirringthe mixture was stirred at room temperature for 2 hours
  4. extractionThe mixture was extracted with ethyl ether
  5. dry with materialdried over magnesium sulfate
  6. customAfter evaporation of the solvent
  7. customthe residue was purified by column chromatography on silica gel eluting with n-hexane/ethyl acetate (=8/2)

出典と根拠

ORDレコード
ord-c27c171ee7d3431da8a285456059b5a1
出典データセット
uspto-grants-1996_05
特許番号
US05519139

反応ノート

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