Hydrochloric Acid → Methyl 3-(4-chlorobenzylidene)-1-methyl-2-oxocylopentanecarboxylate

HRID 440566ノート

反応式

HRID 440566 の反応式
[OH-].[Na+].[CH3:3][C:4]1([C:10]([O:12][CH3:13])=[O:11])[CH2:8][CH2:7][CH2:6][C:5]1=[O:9].[Cl:14][C:15]1[CH:22]=[CH:21][C:18]([CH:19]=O)=[CH:17][CH:16]=1.Cl>O.CO>[Cl:14][C:15]1[CH:22]=[CH:21][C:18]([CH:19]=[C:6]2[CH2:7][CH2:8][C:4]([CH3:3])([C:10]([O:12][CH3:13])=[O:11])[C:5]2=[O:9])=[CH:17][CH:16]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 77264-ChlorobenzaldehydeHCID 14798Sodium HydroxideHCID 121785Cyclopentanecarboxylic acid, 1-methyl-2-oxo-, methyl ester

生成物 1

HCID 67742476Methyl 3-(4-chlorobenzylidene)-1-methyl-2-oxocylopentanecarboxylate

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of 3.4 g of sodium hydroxide in 770 ml of water were added 15 g of methyl 1-methyl-2-oxocylopentanecarboxylate (prepared in Reference Example 1 hereinafter) and a solution of 13.5 g of 4-chlorobenzaldehyde in 800 ml of methanol, and the mixture was stirred for 5 hours at room temperature. The reaction mixture was neutralized with diluted hydrochloric acid and the solvent was evaporated under reduced pressure. The residue was extracted with ethyl acetate. The organic layer was washed with water and dried. Ethyl acetate was evaporated under reduced pressure to obtain 25 g of an oily matter.

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. extractionThe residue was extracted with ethyl acetate
  3. washThe organic layer was washed with water
  4. customdried
  5. customEthyl acetate was evaporated under reduced pressure
  6. customto obtain 25 g of an oily matter

出典と根拠

ORDレコード
ord-c761f163fbaf469d9b12f80f4750cf53
出典データセット
uspto-grants-1996_05
特許番号
US05519160

反応ノート

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