Hydrochloric Acid → 2-Methyl-5-(4-chlorobenzylidene)-cyclopentanone

HRID 440568ノート

反応式

HRID 440568 の反応式
[OH-].[Na+].[Cl:3][C:4]1[CH:21]=[CH:20][C:7]([CH:8]=[C:9]2[CH2:13][CH2:12][C:11](C)([C:14](OC)=O)[C:10]2=[O:19])=[CH:6][CH:5]=1.Cl>O>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([CH:8]=[C:9]2[CH2:13][CH2:12][CH:11]([CH3:14])[C:10]2=[O:19])=[CH:20][CH:21]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67742476Methyl 3-(4-chlorobenzylidene)-1-methyl-2-oxocylopentanecarboxylate

生成物 1

HCID 537529512-Methyl-5-(4-chlorobenzylidene)-cyclopentanone

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

A solution of 12 g of sodium hydroxide in 20 ml of water was added to 10 g of methyl 3-(4-chloro-benzylidene)-1-methyl-2-oxocylopentanecarboxylate (I-1) (prepared in Example 1). The mixture was stirred for 2 hours at 80° C. The reaction mixture was poured into 10% aqueous solution of hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous sodium sulfate. The solvent was evaporated to obtain 4.1 g of an oily matter (yield, 51.8%).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated
  5. customto obtain
  6. custom4.1 g of an oily matter (yield, 51.8%)

出典と根拠

ORDレコード
ord-23395d6cb26a41428953a5a61b9eee6c
出典データセット
uspto-grants-1996_05
特許番号
US05519160

反応ノート

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