3-Chlorophenol → 4-(3-Chlorophenoxy)benzaldehyde
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.F[C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[O:15])=[CH:12][CH:11]=1.[H-].[Na+]>CN(C)C=O.O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[O:8][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[O:15])=[CH:12][CH:11]=1参加物
6
実験手順
3-Chlorophenol (1.9 g) was stirred with 4-fluoro-benzaldehyde (1.8 g) and sodium hydride (0.46 g of an 80% suspension in oil) in dimethylformamide (50 ml) at 110° C. under an atmosphere of nitrogen for 16 hours. The solution was diluted with water and extracted with diethyl ether. The ethereal extract was dried (Na2SO4), concentrated and purified by chromatography on silica gel eluting with ethyl acetate-petroleum ether (1:9) to give the title compound as a colourless oil.
後処理
- extractionextracted with diethyl ether
- extractionThe ethereal extract
- dry with materialwas dried (Na2SO4)
- concentrationconcentrated
- custompurified by chromatography on silica gel eluting with ethyl acetate-petroleum ether (1:9)
出典と根拠
- ORDレコード
- ord-adf6b17e5a4a457bb97a4f58c785175d
- 出典データセット
- uspto-grants-1996_05
- 特許番号
- US05519163
反応ノート
読み込み中…