Sodium Iodide → Tert-butyl 2-iodoacetate

A mixture of t-butyl chloroacetate (20 g) and sodium iodide (25 g) is stirred in acetone (200 ml) for twenty hours. The acetone is removed by distillation under reduced pressure. The residue is partitioned between diethyl ether (100 ml) and water (50 ml). The ether layer is washed with water, 5% sodium thiosulfate solution, and water. The organic layer is dried over sodium sulfate, and evaporated under reduced pressure. There is obtained 25 grams of t-butyl iodoacetate. NMR: 63.5, 1.38.

1. customThe acetone is removed by distillation under reduced pressure
2. customThe residue is partitioned between diethyl ether (100 ml) and water (50 ml)
3. washThe ether layer is washed with water, 5% sodium thiosulfate solution, and water
4. dry with materialThe organic layer is dried over sodium sulfate
5. customevaporated under reduced pressure

ORDレコード

ord-3fe4f992b9eb42fb843d2e30f01bb3f4

出典データセット

uspto-grants-1996_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05521103