Sulfuric Acid → 7-Nitrobenzofuran-3(2H)-one

HRID 440672ノート

反応式

HRID 440672 の反応式
[N+:1]([C:4]1[C:12]2[O:11][CH:10](C(OCC)=O)[C:9](=[O:18])[C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-:3])=[O:2].[OH-].[Na+].S(=O)(=O)(O)O>>[N+:1]([C:4]1[C:12]2[O:11][CH2:10][C:9](=[O:18])[C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 22404730Ethyl 2,3-dihydro-7-nitrobenzofuran-3-on-2-ylcarboxylate

生成物 1

HCID 224047597-Nitrobenzofuran-3(2H)-one

実験手順

In a flask 3.77 g (0.015 mole) of ethyl 2,3-dihydro-7-nitrobenzofuran-3-on-2-ylcarboxylate is suspended in 75 mL of a 5% aqueous solution of sodium hydroxide which is heated at reflux until all solid has gone into solution. The solution is cooled to ambient temperature, and dilute sulfuric acid is added cautiously until there is no further evidence of decarboxylation. The product is extracted with ethyl acetate, and the combined extracts are dried over anhydrous magnesium sulfate and filtered. The filtrate is evaporated under reduced pressure, leaving 2,3-dihydro-7-nitro-3-benzofuranone as a residue.

後処理

  1. temperatureis heated
  2. temperatureat reflux until all solid
  3. extractionThe product is extracted with ethyl acetate
  4. dry with materialthe combined extracts are dried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customThe filtrate is evaporated under reduced pressure

出典と根拠

ORDレコード
ord-ae92de2aaec94a80a92b0831b3386e8d
出典データセット
uspto-grants-1996_05
特許番号
US05521147

反応ノート

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