7-fluoro-2H-chromene → 7-Fluorochroman
反応式
[F:1][C:2]1[CH:11]=[CH:10][C:5]2[CH:6]=[CH:7][CH2:8][O:9][C:4]=2[CH:3]=1.[H][H]>[Pd].C(O)C>[F:1][C:2]1[CH:11]=[CH:10][C:5]2[CH2:6][CH2:7][CH2:8][O:9][C:4]=2[CH:3]=1参加物
5
実験手順
A mixture of 12.1 grams (0.081 mole) of 7-fluoro-2H-1-benzopyran and a catalytic amount of 5% palladium on carbon in about 200 mL of ethanol was shaken in a Parr hydrogenator until the theoretical amount of hydrogen gas was taken up. After this time the reaction mixture was filtered and concentrated under reduced pressure, yielding 10.5 grams of 3,4-dihydro-7-fluoro-2H-1-benzopyran. The NMR spectrum was consistent with the proposed structure.
後処理
- filtrationAfter this time the reaction mixture was filtered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-464cc3987a914093b3ef2887855b0806
- 出典データセット
- uspto-grants-1996_05
- 特許番号
- US05521147
反応ノート
読み込み中…