反応式
[N+:1]([C:4]1[CH:17]=[CH:16][C:15]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:14][C:5]=1[CH2:6][N:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH:12]=O)([O-])=O.[H][H]>C(O)C.[Pd]>[CH:9]1[CH:10]=[CH:11][N:7]2[CH2:6][C:5]3[CH:14]=[C:15]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:16]=[CH:17][C:4]=3[NH:1][CH2:12][C:8]=12参加物
5
実験手順
A solution of 10.0 g of 1-[2-nitro-5-(ethoxycarbonyl)benzyl]-pyrrole-2-carboxaldehyde in 150 ml of absolute ethanol containing 1.0 g of 10% Pd/C is hydrogenated in a Parr apparatus for 16 hours under 40 psi of hydrogen. The reaction mixture is filtered through a pad of diatomaceous earth and the filtrate concentrated in vacuo to a residue of 5.5 g of the desired product as a solid; mass spectrum (M+H)255.
後処理
- filtrationThe reaction mixture is filtered through a pad of diatomaceous earth
- concentrationthe filtrate concentrated in vacuo to a residue of 5.5 g of the desired product as a solid
出典と根拠
- ORDレコード
- ord-2dc63adf99fb4e9b830546c320820220
- 出典データセット
- uspto-grants-1996_05
- 特許番号
- US05521173
関連ノート
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