N-bromobutanimide → 3,7-Dibromo-2,3-dihydro-2,2-dimethylbenzofuran

HRID 440909

反応式

HRID 440909 の反応式
[Br:1][C:2]1[C:10]2[O:9][C:8]([CH3:12])([CH3:11])[CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Br:13]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:13][CH:7]1[C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([Br:1])[C:10]=2[O:9][C:8]1([CH3:12])[CH3:11]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 2720047-Bromo-2,2-dimethyl-2,3-dihydro-1-benzofuran

生成物 1

HCID 190407783,7-Dibromo-2,3-dihydro-2,2-dimethylbenzofuran

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A stirring mixture of 7.0 grams (0.031 mole) of 7-bromo-2,3-dihydro-2,2-dimethylbenzofuran and 5.5 grams (0.031 mole) of N-bromosuccinimide in 150 mL of carbon tetrachloride is heated to reflux while irradiating with a sun lamp. The refluxing reaction mixture is stirred for about three hours, then it is cooled to ambient temperature. After this time the reaction mixture is washed with two 50 mL portions of aqueous 5% sodium bicarbonate solution, and one 50 mL portion of water. The organic layer is dried with magnesium sulfate and filtered. The filtrate is concentrated under reduced pressure, yielding 3,7-dibromo-2,3-dihydro-2,2-dimethylbenzofuran.

後処理

  1. temperatureis heated
  2. temperatureto reflux
  3. customwhile irradiating with a sun lamp
  4. customThe refluxing reaction mixture
  5. washAfter this time the reaction mixture is washed with two 50 mL portions of aqueous 5% sodium bicarbonate solution, and one 50 mL portion of water
  6. dry with materialThe organic layer is dried with magnesium sulfate
  7. filtrationfiltered
  8. concentrationThe filtrate is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-c03d6b4e781b4f8da42041c79f427f71
出典データセット
uspto-grants-1996_05
特許番号
US05521190

関連ノート

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