Ethanolamine → 2-(Pyrimidin-2-ylamino)ethanol
反応式
Cl[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:8]([CH2:10][NH2:11])[OH:9]>O>[N:3]1[CH:4]=[CH:5][CH:6]=[N:7][C:2]=1[NH:11][CH2:10][CH2:8][OH:9]参加物
4
実験手順
2-Chloropyrimidine (5 g) and ethanolamine (15 ml) were stirred for 2 hours at 140° C. After cooling, the mixture was added to water (200 ml) and continuously extracted with ethyl acetate (500 ml) for 16 hours. The organic extract was dried (MgSO4), filtered and evaporated to dryness. The title compound was obtained as a solid (m.p. 66° C.), following chromatography on silica-gel in 3% methanol in dichloromethane.
後処理
- temperatureAfter cooling
- extractioncontinuously extracted with ethyl acetate (500 ml) for 16 hours
- extractionThe organic extract
- dry with materialwas dried (MgSO4)
- filtrationfiltered
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-cfc4317aedb84c90a04d11b59e2a0d1e
- 出典データセット
- uspto-grants-1996_05
- 特許番号
- US05521201
反応ノート
読み込み中…