Water → 3-Iodo-4-methylbenzoic acid

HRID 44106

反応式

HRID 44106 の反応式
C[O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[C:6]([I:11])[CH:5]=1.[OH-].[Na+].O>CO>[I:11][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[CH3:10])[C:3]([OH:12])=[O:2]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 13614033Methyl 3-iodo-4-methylbenzoate

生成物 1

HCID 6216403-Iodo-4-methylbenzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl-3-Iodo-4-methylbenzoate (3 g, 109 mmol, 1 eq) dissolved in MeOH (30 ml) was added sodium hydroxide (1.3 g, 327 mmol, 3 eq) followed by the addition of water (15 ml). The above solution was stirred at room temperature for 14 h. The solution was concentrated under vacuum, and then added water. The pH of the reaction was bought to 3 using Conc.HCl. The solid obtained was filtered and dried under vacuum. Yield: 2.7 g (96%). 1HNMR (400 MHz, DMSO-d6): δ 2.44 (s, 3H), 7.45 (d, J=8.00 Hz, 1H), 7.85 (d, J=3.18 Hz, 1H), 8.31 (s, 1H).

後処理

  1. concentrationThe solution was concentrated under vacuum
  2. customThe solid obtained
  3. filtrationwas filtered
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-4e88ff1604a94ca7b5dd632420ca3b1e
出典データセット
uspto-grants-2013_09
特許番号
US08536338B2

関連ノート

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