Hydrochloric Acid → HCID 178472909、化合物

HRID 441712

反応式

HRID 441712 の反応式
[O:1]=[C:2]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].Cl.[N:18](OCCCC)=[O:19]>C(O)C>[CH2:7]([O:6][C:4](=[O:5])[C:3](=[N:18][OH:19])[C:2](=[O:1])[CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH3:8]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 10996Butyl nitriteHCID 61162Ethyl 3-oxo-5-phenylpentanoate

生成物 1

HCID 178472909HCID 178472909、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 22.0 g. of ethyl 3-oxo-5-phenylvalerate in 100 ml. of ethanol is added 40 ml. of 38% hydrochloric acid, and after 10 minutes 11.3 ml. of n-butyl nitrite is added thereto. The resulting mixture is allowed to stand at room temperature for 45 minutes, and then the ethanol portion is essentially removed under reduced pressure to obtain an oily residue. The residue is poured into about 500 ml. of water and extracted 3 times with 200 ml. of chloroform. The combined extracts are dried over anhydrous sodium sulfate, then evaporated to obtain the title compound as a residue.

後処理

  1. customthe ethanol portion is essentially removed under reduced pressure
  2. customto obtain an oily residue
  3. additionThe residue is poured into about 500 ml
  4. extractionof water and extracted 3 times with 200 ml
  5. dry with materialThe combined extracts are dried over anhydrous sodium sulfate
  6. customevaporated

出典と根拠

ORDレコード
ord-4fb8438852a245e4809299866b15c965
出典データセット
uspto-grants-1977_08
特許番号
US04042596

関連ノート

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