Phosphorus oxybromide → 2,5-Dibromo-3-methylpyrazine

HRID 441739ノート

反応式

HRID 441739 の反応式
O[C:2]1[C:7]([CH3:8])=[N:6][C:5]([Br:9])=[CH:4][N:3]=1.P(Br)(Br)([Br:12])=O>>[Br:12][C:2]1[C:7]([CH3:8])=[N:6][C:5]([Br:9])=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 24613Phosphorus oxybromideHCID 178432449HCID 178432449、化合物

生成物 1

HCID 205289252,5-Dibromo-3-methylpyrazine

反応条件

温度
175 °C

実験手順

A mixture of 2-hydroxy-3-methyl-5-bromopyrazine and phosphorus oxybromide is heated at about 175° C. for several hours with constant stirring. After hydrolysis of the solution on ice the crude product is extracted with ether and distilled. The distillate is refluxed with phosphorus tribromide for several hours and, after cooling, the solution is hydrolyzed on ice and the product extracted with ether, the ether removed in vacuo to give 2,5-dibromo-3-methylpyrazine.

後処理

  1. extractionis extracted with ether
  2. distillationdistilled
  3. temperatureThe distillate is refluxed with phosphorus tribromide for several hours
  4. temperatureafter cooling
  5. extractionthe product extracted with ether
  6. customthe ether removed in vacuo

出典と根拠

ORDレコード
ord-b9ab9e6526bc4d44a67587a462c9af2a
出典データセット
uspto-grants-1977_08
特許番号
US04042586

反応ノート

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