(p-Chlorophenyl)trmethylsilane → HCID 21417831、化合物

HRID 441797ノート

反応式

HRID 441797 の反応式
C[Si](C)(C)C1C=CC(Cl)=CC=1.[Mg].CNC1C=CC=CC=1C=O.[CH3:23][NH:24][C:25]1[CH:42]=[CH:41][C:28]([CH:29]([OH:40])[C:30]2[CH:35]=[CH:34][C:33]([Si:36]([CH3:39])([CH3:38])[CH3:37])=[CH:32][CH:31]=2)=[CH:27][CH:26]=1>N1C=CC=CC=1.O>[CH3:23][NH:24][C:25]1[CH:26]=[CH:27][C:28]([CH:29]([OH:40])[C:30]2[CH:35]=[CH:34][C:33]([Si:36]([CH3:37])([CH3:39])[CH3:38])=[CH:32][CH:31]=2)=[CH:41][CH:42]=1.[CH3:23][NH:24][C:25]1[CH:26]=[CH:27][C:28]([C:29]([C:30]2[CH:35]=[CH:34][C:33]([Si:36]([CH3:38])([CH3:37])[CH3:39])=[CH:32][CH:31]=2)=[O:40])=[CH:41][CH:42]=1

参加物

8

反応物 4

HCID 66351(p-Chlorophenyl)trmethylsilaneHCID 2675692-(methylamino)benzaldehydeHCID 5462224MagnesiumHCID 21417831HCID 21417831、化合物

生成物 2

HCID 21417831HCID 21417831、化合物HCID 21417851HCID 21417851、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 1049Pyridine溶媒2 回

実験手順

4-Methylamino-4'-trimethylsilylbenzhydrol was prepared by a Grignard reagent formulated from 0.2 mole of 4-trimethylsilylchlorobenzene and 0.2 mole of magnesium with 0.2 mole of N-methylaminobenzaldehyde. 0.4 mole of the thus obtained 4-methylamino-4'-trimethylsilylbenzhydrol was dissolved in pyridine, and to the resultant solution was added, dropwise over a period of 40 hours at room temperature, an oxidizing agent prepared by adding 125 ml of pyridine to a solution of 7.5 ml of water and 12.5 mole of chromic anhydride under agitation while being cooled with water. The reaction product was refined by chromatography using silica gel, to obtain 41 g of 4-methylamino-4'-trimethylsilyl benzophenone in a yield of 38%.

後処理

  1. customan oxidizing agent prepared

出典と根拠

ORDレコード
ord-ec764d0c43b74074811fa9878085baf4
出典データセット
uspto-grants-1977_08
特許番号
US04042613

反応ノート

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