6-Phenyl-2-pyridone → Z-Val-Val-OMe

HRID 441891

反応式

HRID 441891 の反応式
[Na].C(C1C=C[C:7]([OH:10])=[N:8]C=1)#N.[OH:11][C:12]1C=C(OC)C=CN=1.[OH:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]2[CH:32]=CC=C[CH:28]=2)[N:22]=1.[OH:33][C:34]1C=CC=C(CCC2C=CC=CC=2)N=1.[OH:48][C:49]1[C:58]2[C:53](=[CH:54][CH:55]=[CH:56][CH:57]=2)C=CN=1.O[C:60]1C=CC=CN=1>>[CH3:12][O:11][C:34](=[O:33])[C@H:23]([CH:27]([CH3:28])[CH3:32])[NH:22][C:21](=[O:20])[C@H:26]([CH:25]([CH3:24])[CH3:60])[NH:8][C:7]([O:48][CH2:49][C:58]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)=[O:10]

参加物

8

反応物 7

HCID 878896-Phenyl-2-pyridoneHCID 5360545SodiumHCID 70621976-HydroxynicotinonitrileHCID 178493244HCID 178493244、化合物HCID 1785160016-(2-Phenylethyl)pyridin-2(1h)-oneHCID 178516071HCID 178516071、化合物HCID 178517620HCID 178517620、化合物

生成物 1

HCID 12286262Z-Val-Val-OMe

実験手順

When a sodium salt of 6-n-amyl-2-hydroxypyridine, 5-cyano-2-hydroxypyridine, 2-hydroxy-4-methoxypyridine, 2-hydroxy-6-phenylpyridine, 2-hydroxy-6-phenethylpyridine or 1-hydroxyisoquinoline is used in place of the sodium salt of 2-hydroxypyridine, the yields of benzyloxycarbonyl-L-valyl-L-valine methyl ester are 72, 83, 81, 76, 80 and 73 percent, respectively.

出典と根拠

ORDレコード
ord-8bd821eceeac4e6bb644a6d057221ae8
出典データセット
uspto-grants-1977_08
特許番号
USRE029369

関連ノート

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