1-Piperazinecarboxylic acid, ethyl ester → 1-Carbethoxy-4-(10,11-dihydro-3-methoxy-8-methylthio-dibenzo[b,f]thiepin-10-yl)-piperazine
反応式
Cl[CH:2]1[C:8]2[CH:9]=[C:10]([S:13][CH3:14])[CH:11]=[CH:12][C:7]=2[S:6][C:5]2[CH:15]=[C:16]([O:19][CH3:20])[CH:17]=[CH:18][C:4]=2[CH2:3]1.[C:21]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)([O:23][CH2:24][CH3:25])=[O:22]>C(Cl)(Cl)Cl>[C:21]([N:26]1[CH2:31][CH2:30][N:29]([CH:2]2[C:8]3[CH:9]=[C:10]([S:13][CH3:14])[CH:11]=[CH:12][C:7]=3[S:6][C:5]3[CH:15]=[C:16]([O:19][CH3:20])[CH:17]=[CH:18][C:4]=3[CH2:3]2)[CH2:28][CH2:27]1)([O:23][CH2:24][CH3:25])=[O:22]参加物
4
実験手順
24 G. of 10-chloro-10,11-dihydro-3-methoxy-8-methylthio-dibenzo[b,f]thiepin in 100 ml. of chloroform are heated with 55 ml. of 1-carbethoxypiperazine under reflux conditions for 20 hours. The mixture is poured on to ice/water and extracted with chloroform. The organic phase is dried over magnesium sulfate and evaporated under reduced pressure, whereby there is obtained crude 1-carbethoxy-4-(10,11-dihydro-3-methoxy-8-methylthio-dibenzo[b,f]thiepin-10-yl)-piperazine.